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CAS No.: 546-43-0

土木香内酯 Catalog No. CSN16394

Synonyms: (+)-Alantolactone;Alant camphor;Inula camphor

Alantolactone is a sesquiterpene lactone with potential activity against triple-negative breast cancer MDA-MB-231 cells by suppressing the signal transducer and activator of transcription 3 (STAT3) signaling pathway.

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技术信息

生物活性

描述Alantolactone is a sesquiterpene lactone extracted from Inula Helenium L with anti-inflammatory, antibacterial and anticancer activities. The half maximal inhibitory effect of alantolactone on cell proliferation concentration (IC50) was 35.45 μΜ at 24 h and 24.29 μΜ at 48 h. In addition, alantolactone at 10, 20 and 30 μΜ significantly downregulated the expression levels of MMP-2, MMP-7 and MMP-9 (matrix metalloproteinase ) protein^[3]. Moreover, alantolactone induced apoptosis in HepG2 cells in a dose-dependent manner. The IC50 value of alantolactone was 33 μM after 12 h treatment^[5].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 4.3044 mL
- 21.5222 mL
- 43.0444 mL
- 5 mM
- 0.8609 mL
- 4.3044 mL
- 8.6089 mL
- 10 mM
- 0.4304 mL
- 2.1522 mL
- 4.3044 mL

技术信息

CAS号

546-43-0

储存条件

粉末: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C15H20O2

运输

蓝冰

分子量

232.32

别名

(+)-Alantolactone;Alant camphor;Inula camphor;Helenin;Helenine;Eupatal;NSC 333843;NSC 93131;AI3-31147;土木香内酯

溶解度

DMSO	44.0 mg/mL (189.4 mM)
Water	Insoluble
Ethanol	45.0 mg/mL (193.7 mM)

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